Ocellarless (Oce)

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Description
"Ocellarless (Oce) is a mutant that was first discovered in 1959 at the genesis of the field of Drosophila mutagenesis (Fahmy and Fahmy, 1959). Since its discovery, Oce has been associated with three key phenotypes, some which affect ocellar complex structures—reduction of ocellar bristles—a clipped wing phenotype, and a gap in the lateral (L5) wing vein. Besides this, the Oce phenotype has not been well characterized, nor mapped to a gene. All prior experiments that attempted to map Oce have consistently failed to do so. Our goal was to accomplish two things: characterize the Oce phenotype and to map the trait to its gene. We determined that among the Oce-associated traits, some are X-linked (reduced number of ocellar bristles and shortened L5 wing veins) and the clipped wing phenotype is autosomal. Through various three-point, duplication, and complementation experiments, we were able to narrow down the Oce locus position somewhere between 1.5 and 3.0 map units (m.u.) from the left end of the X chromosome, refuting all prior literature, and highlighting Notch (N) as a candidate gene. Although further experimentation is required, specifically N sequencing in Oce flies, the genetic evidence provided by our complementation test with N alleles suggest that Oce is not only an allele of N but may also reside within the Notch Abruptex (Ax) region. These findings will serve as a foundation for future experiments to (1) definitively map Oce and (2) hypothesize underlying genetic interactions that lead to the development of the ocellar complex structures."

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File details
ID Label Size Mimetype Created
OBJ OBJ datastream * 20.3 MiB application/pdf 2021-05-29
TN TN 3.23 KiB image/jpeg 2021-05-29
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