Real-Time Characterization of Tachykinin-1-(Tac1)-Expressing Neuron Activity in the Parasubthalamic Nucleus Based on Food Accessibility

We're sorry. Some content is restricted until Saturday 30th of May, 2026. Try logging in for greater access. (See file details below.)
Description
"The motivation to eat is regulated by the relative balance of activity in appetite-inducing and appetite-suppressing neuronal populations in the brain. The parasubthalamic nucleus (PSTN) is a relatively uncharacterized region in the brain that has been implicated as a potential appetite suppression center. While studies have begun to characterize the role of the PSTN in appetite regulation, the activity dynamics of neurons in the PSTN remains largely unknown. This study characterized the real-time activity of tachykinin-1 (Tac1)-expressing neurons based on food accessibility. Specifically, we tested the following hypothesis: accessible food will cause a greater increase in PSTN activity in food-deprived mice than inaccessible food. While Tac1 PSTN neuron activity increased for both accessible and inaccessible food, there was no significant difference in the amount of PSTN neuron activity for accessible versus inaccessible food. Though this hypothesis remains to be fully assessed, we suggest that Tac1 PSTN neurons respond differentially based on food presentation."

In collections

File details
ID Label Size Mimetype Created
OBJ OBJ datastream * 4.49 MiB application/pdf 2021-05-29
TN TN 3.81 KiB image/jpeg 2021-05-29
* We're sorry. Some content is restricted until Saturday 30th of May, 2026. Try logging in for greater access.
Contact Archives and Special Collections with questions at [email protected]