Characterization of AgRP Neuron ActivityAcross the Sleep/Wake Cycle in Food-Deprived Mice

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Description
"Hunger and sleep are competing homeostatic processes. In mammals, agouti-related peptide (AgRP) neurons are both necessary and sufficient for feeding behaviors. It is unknown how sleep affects AgRP neuron activity in food-deprived mice. In this thesis, we recorded AgRP neurons with in vivo calcium imaging using fiber photometry in food-deprived mice and found sleep-state dependent changes in AgRP neuron activity. We found two distinct transition types—regular transitions that are characterized by long periods of sleep followed by long periods of wakefulness, and micro-transitions that are characterized by long periods of sleep followed by intermittent periods of wakefulness. During transitions, AgRP activity increases from NREM sleep to wake and decreases from wake to NREM sleep. Prior to a micro-transition into a wake-state from NREM sleep, AgRP neurons exhibit acute hyperactivity. REM sleep generally coincides with a spike in AgRP neural activity. These results demonstrate that AgRP neural activity is sleep state-dependent. "

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* We're sorry. Some content is restricted until Thursday 28th of May, 2026.
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